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Fertility Drugs and Moods (specifically anxiety)

I have an anxiety disorder (mostly OCD but overall anxiety) and I think I may have PCOS too. I am seeing my gyno about it in the upcoming weeks. If it's a positive diagnosis it sure would answer a lot of questions!

I was just wondering if Clomid and other fertility drugs have an affect on your anxiety? I am a little nervous about being super mood swingy. Look at me being anxious about being anxious (oh, brother)! 

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Re: Fertility Drugs and Moods (specifically anxiety)

  • They can definitely cause anxiety, depression & mood swings, whether you have a history of it or not. Many times, it is not realized until after the clinical trials that the meds can exacerbate an existing condition. I had this happen with chantix when I quit smoking (had no history of anxiety myself, but it is in the family), and I still deal with anxiety and panic attacks today and it took that drug for only 1 month almost 3 years ago. Simply put, these kinds of drugs cause chemical reactions in the brain and anxiety, suicidal thoughts, etc. are all possible by-products of that. It's just something you will need to keep an eye on if you do end up taking, and then talk to your doctor if you start to notice anything out of the ordinary. I have noticed that I am a bit more anxious and prone to feel like an attack is coming on, but that could also be because infertility has really stressed me out. HTH!

    Here is a tidbit I found on clomid:

    Adverse Reactions

    Clinical Trial Adverse Events

    Clomid, at recommended dosages, is generally well tolerated. Adverse reactions usually have been mild and transient and most have disappeared promptly after treatment has been discontinued. Adverse experiences reported in patients treated with clomiphene citrate during clinical studies are shown in Table 2.

    Table 2. Incidence of Adverse Events in Clinical Studies (Events Greater than 1%) (n = 8029*)
    Adverse Event %
    * Includes 498 patients whose reports may have been duplicated in the event totals and could not be distinguished as such. Also, excludes 47 patients who did not report symptom data.
    Ovarian Enlargement 13.6
    Vasomotor Flushes 10.4
    Abdominal-Pelvic Discomfort/Distention/Bloating 5.5
    Nausea and Vomiting 2.2
    Breast Discomfort 2.1
    Visual Symptoms 1.5
      Blurred vision, lights, floaters, waves, unspecified visual complaints, photophobia, diplopia, scotomata, phosphenes
    Headache 1.3
    Abnormal Uterine Bleeding 1.3
      Intermenstrual spotting, menorrhagia

    The following adverse events have been reported in fewer than 1% of patients in clinical trials: Acute abdomen, appetite increase, constipation, dermatitis or rash, depression, diarrhea, dizziness, fatigue, hair loss/dry hair, increased urinary frequency/volume, insomnia, light-headedness, nervous tension, vaginal dryness, vertigo, weight gain/loss.

    Patients on prolonged Clomid therapy may show elevated serum levels of desmosterol. This is most likely due to a direct interference with cholesterol synthesis. However, the serum sterols in patients receiving the recommended dose of Clomid are not significantly altered. Ovarian cancer has been infrequently reported in patients who have received fertility drugs. Infertility is a primary risk factor for ovarian cancer; however, epidemiology data suggest that prolonged use of clomiphene may increase the risk of a borderline or invasive ovarian tumor.

    Postmarketing Adverse Events

    The following adverse experiences were reported spontaneously with Clomid. The cause and effect relationship of the listed events to the administration of Clomid is not known.

    Dermatologic: Acne, allergic reaction, erythema, erythema multiforme, erythema nodosum, hypertrichosis, pruritus

    Central Nervous System: Migraine headache, paresthesia, seizure, stroke, syncope

    Psychiatric: Anxiety, irritability, mood changes, psychosis

    Visual Disorders: Abnormal accommodation, cataract, eye pain, macular edema, optic neuritis, photopsia, posterior vitreous detachment, retinal hemorrhage, retinal thrombosis, retinal vascular spasm, temporary loss of vision

    Cardiovascular: Arrhythmia, chest pain, edema, hypertension, palpitation, phlebitis, pulmonary embolism, shortness of breath, tachycardia, thrombophlebitis

    Musculoskeletal: Arthralgia, back pain, myalgia

    Hepatic: Transaminases increased, hepatitis

    Neoplasms: Liver (hepatic hemangiosarcoma, liver cell adenoma, hepatocellular carcinoma); breast (fibrocystic disease, breast carcinoma); endometrium (endometrial carcinoma); nervous system (astrocytoma, pituitary tumor, prolactinoma, neurofibromatosis, glioblastoma multiforme, brain abcess); ovary (luteoma of pregnancy, dermoid cyst of the ovary, ovarian carcinoma); trophoblastic (hydatiform mole, choriocarcinoma); miscellaneous (melanoma, myeloma, perianal cysts, renal cell carcinoma, Hodgkin's lymphoma, tongue carcinoma, bladder carcinoma); and neoplasms of offspring (neuroectodermal tumor, thyroid tumor, hepatoblastoma, lymphocytic leukemia)

    Genitourinary: Endometriosis, ovarian cyst (ovarian enlargement or cysts could, as such, be complicated by adnexal torsion), ovarian hemorrhage, tubal pregnancy, uterine hemorrhage

    Body as a Whole: Fever, tinnitus, weakness

    Other: Leukocytosis, thyroid disorder

    Fetal/Neonatal Anomalies

    The following fetal abnormalities have also been reported during postmarketing surveillance: delayed development; abnormal bone development including skeletal malformations of the skull, face, nasal passages, jaw, hand, limb (ectromelia including amelia, hemimelia, and phocomelia), foot, and joints; tissue malformations including imperforate anus, tracheoesophageal fistula, diaphragmatic hernia, renal agenesis and dysgenesis, and malformations of the eye and lens (cataract), ear, lung, heart (ventricular septal defect and tetralogy of Fallot), and genitalia; as well as dwarfism, deafness, mental retardation, chromosomal disorders, and neural tube defects (including anencephaly).

    Lilypie Pregnancy tickers 
    Lilypie Second Birthday tickers 
    After 22 cycles and 4 failed IUIs, Serafina joined our family through IVF/ICSI, born 8.28.12
    Surprise! The Sequel is due 12.8.14!

  • Clomid sometimes make me cry for a day at any little thing but I haven't seen any anxiety problems at all.  And I am taking a BIG dose of Clomid.
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